Help with Kali

Hey guys I have a problem that I was hoping you guys could help me out with. I've tried installing KALI for weeks now and have run into a plethora of problems. They ranged from wonky boot options (since my computer is brand new) to the ISO not being readable in disc format, to the live usb becoming totally un recognizable to the computer. While all these problems were solved after googling around, I think now I've hit a stone wall. Certain apps work only sometimes, and when they don't the same 'input/output' error notification appears on the console. I still am not able to find a solution and it is extremely frustrating. Could someone help me out please? Thank you!

P.S.

For configuring persistence mode, all I have to do is click on the 'persistence encrypted' option right? This means all updates are saved right? Thanks!