Unable to Run MS Word Exploit on Victim Due to Windows-Defender

Hey guys, I wanted to know how to evade the windows-defender antivirus so I can run the MS Word exploit exploit/windows/fileformat/ms10087rtfpfragmentsbof. As soon as I try to run it on any victim system , the antivirus deletes the file and I am unable to successfully exploit the system.

Thanks in Advance,